Search results for "Coiled coil"

showing 2 items of 2 documents

Coiled-Coil Lipopeptides Mimicking the Prehairpin Intermediate of Glycoprotein gp41

2009

Protein ConformationMolecular Sequence DataRetroviridae ProteinsPeptideGp41CatalysisLipopeptides03 medical and health sciences0302 clinical medicineAnimalsAmino Acid Sequence030304 developmental biologychemistry.chemical_classificationCoiled coil0303 health sciencesMembrane GlycoproteinsPhosphatidylethanolaminesMolecular MimicryGeneral ChemistryGeneral MedicineVirus InternalizationAnti-Retroviral AgentschemistryBiochemistryPhosphatidylcholinesGlycoprotein030217 neurology & neurosurgeryAngewandte Chemie
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Protein-protein interactions can be predicted using coiled coil co-evolution patterns

2016

AbstractProtein-protein interactions are sometimes mediated by coiled coil structures. The evolutionary conservation of interacting orthologs in different species, along with the presence or absence of coiled coils in them, may help in the prediction of interacting pairs. Here, we illustrate how the presence of coiled coils in a protein can be exploited as a potential indicator for its interaction with another protein with coiled coils. The prediction capability of our strategy improves when restricting our dataset to highly reliable, known protein-protein interactions. Our study of the co-evolution of coiled coils demonstrates that pairs of interacting proteins can be distinguished from no…

0301 basic medicineStatistics and ProbabilityComputational biologyCorrelated evolutionGeneral Biochemistry Genetics and Molecular BiologyProtein Structure SecondaryProtein–protein interactionConserved sequenceEvolution Molecular03 medical and health sciencesProtein-protein interactionModelling and SimulationImmunology and Microbiology(all)Coiled coilGeneticsCoiled coilPhysicsMedicine(all)030102 biochemistry & molecular biologyGeneral Immunology and MicrobiologyAgricultural and Biological Sciences(all)Models GeneticBiochemistry Genetics and Molecular Biology(all)Applied MathematicsA proteinProteinsGeneral Medicine030104 developmental biologyModeling and SimulationGeneral Agricultural and Biological SciencesJournal of Theoretical Biology
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